skip to Main Content
Making Extraction Productive

By John A. MacKay, Ph.D.


The word is itself sounds harsh. For me, it immediately brings to mind images of a dentist armed with a drill and sharp tools and, of course, pain. I have images like those from Paramount Pictures, 1976 movie, “Marathon Man” with Sir Laurence Olivier and Dustin Hoffman. In the movie Sir Olivier’s character uses dental tools to torture people to talk. The key line in the movie is; “Is it safe?” There are plenty of agonizing torturous screams, intermingled with Mr. Hoffman telling Sir Olivier anything he thinks he wants to hear.

The harsh reality is that extraction of active botanicals ingredients seems to come with as many screams of exasperation and pain as the movie. Of course the questions about safety always come up.

So when, Rob Meagher from CBE Press asked if I would write an article on the principles and practices of extraction, I responded with a proposal to submit a series of short articles on the entire workflow — from planting the seed to plowing the last of the plant back into the soil.

Extraction in all of its forms, (really just a controlled elution of components based on solubility) is just one part of an entire workflow. To make the best of this pivotal part you need to be aware of the entire workflow.

It is critical that science in the lab be balanced with the reality of the people doing the work every day. I believe that the people on the factory floor have always found ways to make things work … and in many cases, they have never read a single paper. These experienced people are the ones who hold the real key to success in the extraction of botanicals.

There will be times when the articles will be concise. During those rare times, it will be because I had more time to prepare. “A member of the cabinet congratulated [President Woodrow] Wilson on introducing the vogue of short speeches and asked him about the time it took him to prepare his speeches. He [Wilson] said: “It depends. If I am to speak ten minutes, I need a week for preparation; if 15 minutes, three days; if half an hour, two days; if an hour, I am ready now. “– from Josephus Daniels, the Wilson Era; Years of War and After, 1917-1923.

More often than not, the articles will be filled with an aspect of the extraction stage, as well as answering some of the questions that were generated from previous articles.

Note, I have no bias on any type of solvent used in extraction. The type of solvent used is dependent upon the scientist’s need for a particular material in a particular set of circumstances. Water, butane, propane, ethanol, hexane, carbon dioxide, etc. — there are many choices. The key is that the mode is safe and the circumstances around them are used in the manner of standards in the industry.

The key is to look at the sample preparation BEFORE it goes in the extraction vessel. For example:

  • What is the relative ratio of active botanicals, waxes and volatile components?
  • What size are the particles?
  • What is the distribution of the particle size?
  • What is the type of particles and distribution?
  • Often moisture is critical to the extraction; does it need to be dried or moistened?
  • Are there other pretreatments necessary?

These are considerations even before we consider the length of the vessel, the internal diameter, and material of construction, flow path, pressure, temperature, desolvation and reclamation of solvents.

So, as we take the journey through the process, all of these factors will be considered, and, the effect that each one has on the overall process. I hope that is it brings you better productivity in your business today, or something you can use in the future.

The first topic to consider is how to choose the method to use for extraction. This is the question that I am most often asked. You must start from the end. If you do not know where you are going then any road will get you there.

What is your goal? What is the formulation that you are trying to make? The key word is “trying”. That is the beginning of Research and Development. Trying IS Research.

Is the formulation needing aromaticity (aromatherapy ingredients) or not? Is the formulation needing to have specific components? And ALL not the right answer. There has to be a priority. There has to be one choice over and another, or a class of compounds over another. There must be decisions that are made BEFORE you decide on the method of extraction or extraction mode.

Let me use a general example of a common dilemma in the medical marijuana application. Volatile compounds. Volatile terpenes and flavors in cannabis will be vaporized during the commonly used heating process of decarboxylation of CBDA to CBD (simple oven). At the temperatures used, and if no means is used to capture the volatile components, then they will be lost in the waste stream.

If you are wanting to capture the volatile components then there are procedures used to capture these components before decarboxylation. For example the essential oils of thyme can be captured with Supercritical Fluid Extraction (SFE) using CO2 at 100 bar and 40C (Chromatographia, Volume 51 No.3/4, February 2000 pg 176), and then step up the pressures to collect the other component families through the use of CO2’s unique properties of increased polarity at increasing pressure (to be covered in next article). The use of n-Butane (on UL approved technology) would be able to capture all of the components. There is less selectivity, but that might well be the BEST technology for the formulation and workflow. We will explore that also.

Does that mean that you have to only do one product?

No, it means you have to be able to adapt your process to the formulation you are making. Too many people forget that there are many ways to use all the plant. There is no waste. Everything has a use. Whether it has a value to your process is another question. One company’s waste is another company’s starting material.

So next article? O=C=O working under pressure. References to theory for those so inclined. Illustrations and word pictures for those more like me. For those that prefer to learn through the voice and lecture a short link to a presentation.   For the hands-on-learner, a couple experiments for you to explore to move from paper to practitioner.

Hoping you extract the best from your day!


John A. MacKay, Ph.D., is the Senior Director, Strategic Technology at Waters Corporation. He earned a B.A. in Chemistry from St. Lawrence University, and Ph.D. from the University of Vermont in chemistry focused on the synthesis for cancer fighting molecules using a cyclic -phosphazene backbone. After positions teaching organic, biochemistry and analytical courses, at Davidson College, Lyndon State College and UVM as well as supervising grant based funded student research projects, John joined Waters Technologies in July, 1983. His career has included many roles in product development and now heads up the newly formed Strategic Technology team for the Americas Business Operations. He is widely recognized as scientific expert in application of supercritical fluid for extraction and chromatography across a wide application space including botanical space.

John can be reached at [email protected], or [T] +1 508 482 2104.

John MacKay

John A. MacKay, Ph.D.

John A. MacKay earned a B.A. in Chemistry from St. Lawrence University (SLU), and a Ph.D. from the University of Vermont (UVM), in Inorganic Chemistry. After positions teaching at Davidson College, Lyndon State College and University of Vermont (UVM), John joined Waters Corporation in 1983. In 1990 John joined Otsuka Electronics as Director of Strategic Development, and then joined Analytical Technology Incorporated, to aid in building a multi-technology company. In 1994, he rejoined Waters after the management buyout from Millipore.

John retired from Waters in March 2017. He founded Synergistic Technologies Associates, LLC works with botanical companies to help maximize their total operations based on Six Sigma principles and practices. In January 2019 he joined New Bridge Global Ventures as the Chief Technology Officer to expand the unique extraction and analytical tools the company will use across its vertical platform.

His career has included many roles in innovative product development and marketing. John is widely recognized as a scientific expert in extraction in the botanical space; he is bringing the synergy from what were disparate technologies together to optimize workflow as well as providing consulting and education services through Genus, NewBridge Global Venture company.

With the expertise and desire to spread the science throughout the industry, John has taken on roles as contributing journalist and science editor for Terpenes and Testing Magazine and was the editor of the early issues of Extraction Magazine and now is contributing journalist and scientific advisor. Synergistic Technologies Associates is focused on the continuing education and source of examining new technologies and practices in the hemp market. He has also been appointed the Educator Assistant Professor on the Volunteer Pathway, Department of Pharmacology at the Robert Larner, MD College of Medicines.

John can be reached at:
[M]+1 774-462-8363
[E] [email protected] or
[E] [email protected]

This Post Has 0 Comments

Leave a Reply

Your email address will not be published. Required fields are marked *

Recent Stories

Groups From 56 Countries Ask UN To Ensure Secretive ‘Cannabis Initiative’ Is Open To Public Scrutiny

ONE year on from the formal recognition of the potential for cannabis as a medicine almost 200 global advocacy and civil society groups are backing for calls for greater transparency over emerging new cannabis guidelines. On December 2, last year the United Nations Commission on Narcotic Drugs (CND) rescheduled cannabis recognising its medical properties for…

San Francisco Suspends Cannabis Tax To Combat Illegal Marijuana Sales

SAN FRANCISCO (BCN) — San Francisco supervisors on Tuesday unanimously approved an ordinance to suspend the city’s Cannabis Business Tax through the end of next year, in an attempt to curb illegal marijuana sales. According to Supervisor Rafael Mandelman, the legislation’s author, suspending the city business tax through Dec. 31, 2022, would help support legal…

Hickenlooper: Law preventing cannabis business banking ‘a recipe for disaster’

Lawmakers on both sides of the aisle said Wednesday that federal law prohibiting cash-only cannabis businesses from using banks must be changed. Despite recreational marijuana being legal in 18 states and the District of Columbia, it is still classified as a Schedule I narcotic under federal law. Banks that provide services to cannabis companies —…

Bipartisan bill aims to add new rules to Florida’s medical marijuana industry

After years of partisan squabbling over the fate of Florida’s medical marijuana program, Democrats and Republicans are coming together to push what they’re calling a major reform bill. It could make it a lot harder for Floridians to get their hands on delta-8 tetrahydrocannabinol (THC) products. Those smokable and edible products have been part of…

More Categories

Back To Top
×Close search